1XH7

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Summary for 1XH7

• Entry DOI: 10.2210/pdb1xh7/pdb
• Related: 1SVE 1SVG 1SVH 1VEB 1XH4 1XH5 1XH6 1XH8 1XH9 1XHA
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-[4-({4-[5-(3,3-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, ... (4 entities in total)
• Functional Keywords: pka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Bos taurus (cattle); More
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43662.48

Authors

Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-09-17, release date: 2005-09-17, Last modification date: 2011-07-13)

• Primary citation: Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B.; Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants; J.Med.Chem., 48:163-170, 2005; PubMed: 15634010; DOI: 10.1021/jm049701n

Experimental method

X-RAY DIFFRACTION (2.47 Å)