1XH2

Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride and acarbose

Summary for 1XH2

Entry DOI	10.2210/pdb1xh2/pdb
Related	1XGZ 1XH0 1XH1
Descriptor	Alpha-amylase, pancreatic, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACARBOSE DERIVED PENTASACCHARIDE, ... (6 entities in total)
Functional Keywords	chloride amylase enzyme acarbose, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57008.77
Authors	Maurus, R.,Begum, A.,Kuo, H.H.,Racaza, A.,Numao, S.,Overall, C.M.,Withers, S.G.,Brayer, G.D. (deposition date: 2004-09-17, release date: 2005-05-24, Last modification date: 2023-10-25)
Primary citation	Maurus, R.,Begum, A.,Kuo, H.H.,Racaza, A.,Numao, S.,Andersen, C.,Tams, J.W.,Vind, J.,Overall, C.M.,Withers, S.G.,Brayer, G.D. Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase PROTEIN SCI., 14:743-755, 2005 Cited by PubMed: 15722449 DOI: 10.1110/ps.041079305 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation