1X9M

T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA

Summary for 1X9M

• Entry DOI: 10.2210/pdb1x9m/pdb
• Related: 1T7P 1X9S 1X9W
• Descriptor: 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*TP*GP*GP*TP*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', 5'-D(*CP*CP*CP*(8FG)P*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', DNA polymerase, ... (6 entities in total)
• Functional Keywords: dna ploymerase, n-2-acetylaminofluorene, replication block, mutagenesis, transferase-electron transport-dna complex, transferase/electron transport/dna
• Biological source: Enterobacteria phage T7; More
• Total number of polymer chains: 4
• Total formula weight: 105706.24

Authors

Dutta, S.,Li, Y.,Johnson, D.,Dzantiev, L.,Richardson, C.C.,Romano, L.J.,Ellenberger, T. (deposition date: 2004-08-23, release date: 2004-10-26, Last modification date: 2024-02-14)

• Primary citation: Dutta, S.,Li, Y.,Johnson, D.,Dzantiev, L.,Richardson, C.C.,Romano, L.J.,Ellenberger, T.; Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.; Proc.Natl.Acad.Sci.USA, 101:16186-16191, 2004; PubMed: 15528277; DOI: 10.1073/pnas.0406516101

Experimental method

X-RAY DIFFRACTION (2.1 Å)