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1WCO

The solution structure of the nisin-lipid II complex

Replaces:  1UZT
Summary for 1WCO
Entry DOI10.2210/pdb1wco/pdb
Related1AJ1 1MQX 1MQY 1MQZ 1QOW 1W9N 2DDE 2KTN 2KTO
Related PRD IDPRD_000200
DescriptorALA-FGA-LYS-DAL-DAL PEPTIDE, Lantibiotic, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-alpha-muramic acid, ... (4 entities in total)
Functional Keywordspeptide-antibiotic complex, lantibiotic, antimicrobial, bacteriocin, thioester, pore formation, pyrophosphate cage, food preservative, peptide/antibiotic
Biological sourceMONARTHROPALPUS FLAVUS
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Total number of polymer chains2
Total formula weight4749.46
Authors
Hsu, S.-T.D.,Breukink, E.,Tischenko, E.,Lutters, M.A.G.,de Kruijff, B.,Kaptein, R.,Bonvin, A.M.J.J.,van Nuland, N.A.J. (deposition date: 2004-11-19, release date: 2005-03-07, Last modification date: 2020-07-29)
Primary citationHsu, S.T.,Breukink, E.,Tischenko, E.,Lutters, M.A.,de Kruijff, B.,Kaptein, R.,Bonvin, A.M.,van Nuland, N.A.
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.
Nat. Struct. Mol. Biol., 11:963-967, 2004
Cited by
PubMed: 15361862
DOI: 10.1038/nsmb830
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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