1WCH

Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket

Summary for 1WCH

Entry DOI	10.2210/pdb1wch/pdb
Related	1D5G 1Q7X 3PDZ
Descriptor	PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13, PHOSPHATE ION (3 entities in total)
Functional Keywords	hydrolase, tyrosine phosphatase, phosphate ion, colorectal cancer alternative splicing, coiled coil, cytoskeleton, polymorphism, structural protein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36372.46
Authors	Villa, F.,Deak, M.,Bloomberg, G.B.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2004-11-16, release date: 2004-12-14, Last modification date: 2023-12-13)
Primary citation	Villa, F.,Deak, M.,Bloomberg, G.B.,Alessi, D.R.,Van Aalten, D.M.F. Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket J.Biol.Chem., 280:8180-, 2005 Cited by PubMed: 15611135 DOI: 10.1074/JBC.M412211200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation