1WBS

Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.

Summary for 1WBS

Entry DOI	10.2210/pdb1wbs/pdb
Related	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZZ2 1ZZL
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 14, 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	p38, map kinase, inhibitor structure, alternative splicing, atp-binding, nuclear protein, phosphorylation, serine/threonine protein kinase, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	41879.79
Authors	Tickle, J.,Cleasby, A.,Devine, L.A.,Jhoti, H. (deposition date: 2004-11-05, release date: 2005-11-03, Last modification date: 2011-07-13)
Primary citation	Gill, A.L.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.C.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.,Jhoti, H. Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation. J.Med.Chem., 48:414-, 2005 Cited by PubMed: 15658855 DOI: 10.1021/JM049575N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation