1W51

BACE (Beta Secretase) in complex with a nanomolar non-peptidic inhibitor

Summary for 1W51

Entry DOI	10.2210/pdb1w51/pdb
Related	1FKN 1M4H 1PY1 1SGZ 1UJJ 1UJK 1W50
Descriptor	BETA-SECRETASE 1, IODIDE ION, 3-[({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)(HYDROXY)METHYL]-N,N-DIPROPYLBENZAMIDE, ... (4 entities in total)
Functional Keywords	hydrolase/inhibitor, hydrolase-inhibitor complex, alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46861.75
Authors	Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J. (deposition date: 2004-08-04, release date: 2004-09-23, Last modification date: 2023-12-13)
Primary citation	Patel, S.,Vuillard, L.,Cleasby, A.,Murray, C.W.,Yon, J. Apo and Inhibitor Complex Structures of Bace (Beta-Secretase) J.Mol.Biol., 343:407-, 2004 Cited by PubMed: 15451669 DOI: 10.1016/J.JMB.2004.08.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation