1VXO

METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

1VXO の概要

• エントリーDOI: 10.2210/pdb1vxo/pdb
• 分子名称: PROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, ... (4 entities in total)
• 機能のキーワード: cholinesterase, organophosphate, serine hydrolase, chemical-warfare, hydrolase
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61257.95

構造登録者

Millard, C.B.,Silman, I.,Sussman, J.L. (登録日: 1999-04-21, 公開日: 1999-11-15, 最終更新日: 2023-08-23)

• 主引用文献: Millard, C.B.,Koellner, G.,Ordentlich, A.,Shafferman, A.,Silman, I.,Sussman, J.L.; Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad; J.Am.Chem.Soc., 121:9883-9884, 1999; DOI: 10.1021/ja992704i

実験手法

X-RAY DIFFRACTION (2.4 Å)