1VSN

Crystal structure of a potent small molecule inhibitor bound to cathepsin K

Replaces:  2FDZ

Summary for 1VSN

• Entry DOI: 10.2210/pdb1vsn/pdb
• Descriptor: Cathepsin K, N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: osteoporosis, structure-guided drug design, proteae, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23517.27

Authors

McGrath, M. (deposition date: 2007-03-19, release date: 2007-04-24, Last modification date: 2023-12-27)

• Primary citation: Li, C.S.,Deschenes, D.,Desmarais, S.,Falgueyret, J.P.,Gauthier, J.Y.,Kimmel, D.B.,McGrath, M.E.,McKay, D.J.,Percival, M.D.,Riendeau, D.,Rodan, S.B.,Truong, V.L.,Wesolowski, G.,Zamboni, R.,Black, W.C.; Identification of a potent and selective non-basic cathepsin K inhibitor.; Bioorg.Med.Chem.Lett., 16:1985-1989, 2006; PubMed: 16413777; DOI: 10.1016/j.bmcl.2005.12.071

Experimental method

X-RAY DIFFRACTION (2 Å)