1VR1

Specifity for Plasminogen Activator Inhibitor-1

1VR1 の概要

• エントリーDOI: 10.2210/pdb1vr1/pdb
• 分子名称: thrombin, Hirudin, ... (4 entities in total)
• 機能のキーワード: thrombin, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 34738.76

構造登録者

Dekker, R.J.,Eichinger, A.,Stoop, A.A.,Bode, W.,Pannekoek, H.,Horrevoets, A.J.G. (登録日: 1998-12-11, 公開日: 1999-12-29, 最終更新日: 2022-12-21)

• 主引用文献: Dekker, R.J.,Eichinger, A.,Stoop, A.A.,Bode, W.,Pannekoek, H.,Horrevoets, A.J.G.; The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop; J.Mol.Biol., 293:613-627, 1999; PubMed: 10543954; DOI: 10.1006/jmbi.1999.3178

実験手法

X-RAY DIFFRACTION (1.9 Å)