1VR1

Specifity for Plasminogen Activator Inhibitor-1

Summary for 1VR1

Entry DOI	10.2210/pdb1vr1/pdb
Descriptor	thrombin, Hirudin, ... (4 entities in total)
Functional Keywords	thrombin, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28504
Total number of polymer chains	3
Total formula weight	34738.76
Authors	Dekker, R.J.,Eichinger, A.,Stoop, A.A.,Bode, W.,Pannekoek, H.,Horrevoets, A.J.G. (deposition date: 1998-12-11, release date: 1999-12-29, Last modification date: 2022-12-21)
Primary citation	Dekker, R.J.,Eichinger, A.,Stoop, A.A.,Bode, W.,Pannekoek, H.,Horrevoets, A.J.G. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop J.Mol.Biol., 293:613-627, 1999 Cited by PubMed: 10543954 DOI: 10.1006/jmbi.1999.3178 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation