1VCU

Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA

Summary for 1VCU

Entry DOI	10.2210/pdb1vcu/pdb
Related	1SNT 1SO7
Descriptor	Sialidase 2, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	sialidase, neuraminidase, ganglioside, dana, sialic acid, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	86374.93
Authors	Chavas, L.M.G.,Fusi, P.,Tringali, C.,Venerando, B.,Tettamanti, G.,Kato, R.,Monti, E.,Wakatsuki, S. (deposition date: 2004-03-12, release date: 2004-11-02, Last modification date: 2023-10-25)
Primary citation	Chavas, L.M.G.,Tringali, C.,Fusi, P.,Venerando, B.,Tettamanti, G.,Kato, R.,Monti, E.,Wakatsuki, S. Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION J.Biol.Chem., 280:469-475, 2005 Cited by PubMed: 15501818 DOI: 10.1074/jbc.M411506200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation