1UNQ

High resolution crystal structure of the Pleckstrin Homology Domain Of Protein Kinase B/Akt Bound To Ins(1,3,4,5)-Tetrakisphophate

Summary for 1UNQ

Entry DOI	10.2210/pdb1unq/pdb
Related	1H10 1UNP 1UNR
Descriptor	RAC-ALPHA SERINE/THREONINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE (3 entities in total)
Functional Keywords	transferase, pleckstrin homology domain, pkb, akt, phosphoinositide, serine/threonine-protein kinase, atp-binding, phosphorylation, nuclear protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P31749
Total number of polymer chains	1
Total formula weight	15299.78
Authors	Milburn, C.C.,Deak, M.,Kelly, S.M.,Price, N.C.,Alessi, D.R.,van Aalten, D.M.F. (deposition date: 2003-09-12, release date: 2004-09-16, Last modification date: 2023-12-13)
Primary citation	Milburn, C.C.,Deak, M.,Kelly, S.M.,Price, N.C.,Alessi, D.R.,Van Aalten, D.M. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem. J., 375:531-538, 2003 Cited by PubMed: 12964941 DOI: 10.1042/BJ20031229 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.98 Å)

Structure validation