1UNP

Crystal structure of the pleckstrin homology domain of PKB alpha

Summary for 1UNP

• Entry DOI: 10.2210/pdb1unp/pdb
• Related: 1H10 1UNQ 1UNR
• Descriptor: RAC-ALPHA SERINE/THREONINE KINASE (2 entities in total)
• Functional Keywords: pleckstrin homology domain, transferase, phosphoinositide, pkb, akt
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P31749
• Total number of polymer chains: 1
• Total formula weight: 14542.46

Authors

Milburn, C.C.,Deak, M.,Kelly, S.M.,Price, N.C.,Alessi, D.R.,van Aalten, D.M.F. (deposition date: 2003-09-12, release date: 2004-09-16, Last modification date: 2023-12-13)

• Primary citation: Milburn, C.C.,Deak, M.,Kelly, S.M.,Price, N.C.,Alessi, D.R.,Van Aalten, D.M.; Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.; Biochem. J., 375:531-538, 2003; PubMed: 12964941; DOI: 10.1042/BJ20031229

Experimental method

X-RAY DIFFRACTION (1.65 Å)