1UK0

Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

Summary for 1UK0

• Entry DOI: 10.2210/pdb1uk0/pdb
• Related: 1UK1
• Descriptor: Poly [ADP-ribose] polymerase-1, 2-{3-[4-(4-FLUOROPHENYL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]PROPYL}-8-METHYL-4(3H)-QUINAZOLINONE (3 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P09874
• Total number of polymer chains: 2
• Total formula weight: 79148.64

Authors

Kinoshita, T. (deposition date: 2003-08-13, release date: 2004-01-27, Last modification date: 2023-12-27)

• Primary citation: Kinoshita, T.,Nakanishi, I.,Warizaya, M.,Iwashita, A.,Kido, Y.,Hattori, K.,Fujii, T.; Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.; Febs Lett., 556:43-46, 2004; PubMed: 14706823; DOI: 10.1016/S0014-5793(03)01362-0

Experimental method

X-RAY DIFFRACTION (3 Å)