1UEA

MMP-3/TIMP-1 COMPLEX

1UEA の概要

• エントリーDOI: 10.2210/pdb1uea/pdb
• 分子名称: MATRIX METALLOPROTEINASE-3, TISSUE INHIBITOR OF METALLOPROTEINASE-1, ZINC ION, ... (5 entities in total)
• 機能のキーワード: proteinase, zinc-endopeptidase, proteinase inhibitor, complex, mmps (matrix metallo proteinases) timps (tissue inhibitor of metallo proteinases), metzincins, complex (metalloprotease-inhibitor), complex (metalloprotease-inhibitor) complex, complex (metalloprotease/inhibitor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P08254; Secreted: P01033
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 80816.33

構造登録者

Bode, W.,Maskos, K.,Gomis-Rueth, F.-X.,Nagase, H. (登録日: 1997-06-06, 公開日: 1998-10-14, 最終更新日: 2021-11-03)

• 主引用文献: Gomis-Ruth, F.X.,Maskos, K.,Betz, M.,Bergner, A.,Huber, R.,Suzuki, K.,Yoshida, N.,Nagase, H.,Brew, K.,Bourenkov, G.P.,Bartunik, H.,Bode, W.; Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.; Nature, 389:77-81, 1997; PubMed: 9288970; DOI: 10.1038/37995

実験手法

X-RAY DIFFRACTION (2.8 Å)