1UEA

MMP-3/TIMP-1 COMPLEX

Summary for 1UEA

Entry DOI	10.2210/pdb1uea/pdb
Descriptor	MATRIX METALLOPROTEINASE-3, TISSUE INHIBITOR OF METALLOPROTEINASE-1, ZINC ION, ... (5 entities in total)
Functional Keywords	proteinase, zinc-endopeptidase, proteinase inhibitor, complex, mmps (matrix metallo proteinases) timps (tissue inhibitor of metallo proteinases), metzincins, complex (metalloprotease-inhibitor), complex (metalloprotease-inhibitor) complex, complex (metalloprotease/inhibitor)
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P08254 Secreted: P01033
Total number of polymer chains	4
Total formula weight	80816.33
Authors	Bode, W.,Maskos, K.,Gomis-Rueth, F.-X.,Nagase, H. (deposition date: 1997-06-06, release date: 1998-10-14, Last modification date: 2021-11-03)
Primary citation	Gomis-Ruth, F.X.,Maskos, K.,Betz, M.,Bergner, A.,Huber, R.,Suzuki, K.,Yoshida, N.,Nagase, H.,Brew, K.,Bourenkov, G.P.,Bartunik, H.,Bode, W. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature, 389:77-81, 1997 Cited by PubMed: 9288970 DOI: 10.1038/37995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation