1U6Q

Substituted 2-Naphthamadine inhibitors of Urokinase

Summary for 1U6Q

Entry DOI	10.2210/pdb1u6q/pdb
Related	1owd 1owe 1owh 1owi 1owj 1sqa
Descriptor	Urokinase-type plasminogen activator, TRANS-6-(2-PHENYLCYCLOPROPYL)-NAPHTHALENE-2-CARBOXAMIDINE (2 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00749
Total number of polymer chains	1
Total formula weight	27908.87
Authors	Bruncko, M.,McClellan, W.,Wendt, M.D.,Sauer, D.R.,Geyer, A.,Dalton, C.R.,Kaminski, M.K.,Nienaber, V.L.,Rockway, T.R.,Giranda, V.L. (deposition date: 2004-07-30, release date: 2004-10-19, Last modification date: 2011-07-13)
Primary citation	Bruncko, M.,McClellan, W.J.,Wendt, M.D.,Sauer, D.R.,Geyer, A.,Dalton, C.R.,Kaminski, M.A.,Weitzberg, M.,Gong, J.,Dellaria, J.F.,Mantei, R.,Zhao, X.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Bouska, J.,Rockway, T.W.,Giranda, V.L. Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg.Med.Chem.Lett., 15:93-98, 2005 Cited by PubMed: 15582418 DOI: 10.1016/j.bmcl.2004.10.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation