1U4L

human RANTES complexed to heparin-derived disaccharide I-S

Summary for 1U4L

• Entry DOI: 10.2210/pdb1u4l/pdb
• Related: 1b3a 1eqt 1hrj 1rtn 1rto 1u4m 1u4p 1u4r
• Related PRD ID: PRD_900026
• Descriptor: Small inducible cytokine A5, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETIC ACID, ... (4 entities in total)
• Functional Keywords: chemoattractant, cytokine, chemokine, rantes, glycosaminoglycan, protein-heparin disaccharide complex, attractant
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 16361.54

Authors

Shaw, J.P.,Johnson, Z.,Borlat, F.,Zwahlen, C.,Kungl, A.,Roulin, K.,Harrenga, A.,Wells, T.N.C.,Proudfoot, A.E.I. (deposition date: 2004-07-26, release date: 2004-11-09, Last modification date: 2023-08-23)

• Primary citation: Shaw, J.P.,Johnson, Z.,Borlat, F.,Zwahlen, C.,Kungl, A.,Roulin, K.,Harrenga, A.,Wells, T.N.,Proudfoot, A.E.; The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.; Structure, 12:2081-2093, 2004; PubMed: 15530372; DOI: 10.1016/j.str.2004.08.014

Experimental method

X-RAY DIFFRACTION (2 Å)