2VDN

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide

Replaces:  1TY6

Summary for 2VDN

• Entry DOI: 10.2210/pdb2vdn/pdb
• Related: 2VDK 2VDL 2VDM 2VDO 2VDP 2VDQ 2VDR
• Descriptor: INTEGRIN ALPHA-IIB, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (12 entities in total)
• Functional Keywords: cell adhesion-immune system complex, fibrinogen binding, platelet integrin alphaiibbeta3, glycoprotein, cell adhesion, membrane, integrin, receptor, antagonist, host-virus interaction, pyrrolidone carboxylic acid, transmembrane, phosphorylation, disease mutation, cleavage on pair of basic residues, cell adhesion/immune system
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 5
• Total formula weight: 151190.67

Authors

Springer, T.A.,Zhu, J.,Xiao, T. (deposition date: 2007-10-10, release date: 2008-09-02, Last modification date: 2023-12-13)

• Primary citation: Springer, T.A.,Zhu, J.,Xiao, T.; Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.; J.Cell Biol., 182:791-, 2008; PubMed: 18710925; DOI: 10.1083/JCB.200801146

Experimental method

X-RAY DIFFRACTION (2.9 Å)