1TU6

Cathepsin K complexed with a ketoamide inhibitor

Summary for 1TU6

Entry DOI	10.2210/pdb1tu6/pdb
Descriptor	Cathepsin K, SULFATE ION, [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE, ... (4 entities in total)
Functional Keywords	catk, cysteine protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	2
Total formula weight	48224.15
Authors	Barrett, D.G.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Long, S.T.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Wells-Knecht, K.J.,Wright, L.L. (deposition date: 2004-06-24, release date: 2004-09-21, Last modification date: 2023-08-23)
Primary citation	Barrett, D.G.,Catalano, J.G.,Deaton, D.N.,Hassell, A.M.,Long, S.T.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Wells-Knecht, K.J.,Willard, D.H.,Wright, L.L. Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions BIOORG.MED.CHEM.LETT., 14:4897-4902, 2004 Cited by PubMed: 15341947 DOI: 10.1016/j.bmcl.2004.07.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation