1TQ7

Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK

Summary for 1TQ7

• Entry DOI: 10.2210/pdb1tq7/pdb
• Related PRD ID: PRD_000020
• Descriptor: Prothrombin, ZINC ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (6 entities in total)
• Functional Keywords: thrombin, anticoagulant, blood clotting, ppack, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35444.01

Authors

Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E. (deposition date: 2004-06-16, release date: 2004-08-03, Last modification date: 2024-03-13)

• Primary citation: Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Cantwell, A.M.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E.; The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket; J.Biol.Chem., 279:39824-39828, 2004; PubMed: 15252033; DOI: 10.1074/jbc.M407272200

Experimental method

X-RAY DIFFRACTION (2.4 Å)