1TC2

TERNARY SUBSTRATE COMPLEX OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM TRYPANOSOMA CRUZI

Summary for 1TC2

Entry DOI	10.2210/pdb1tc2/pdb
Descriptor	PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ... (6 entities in total)
Functional Keywords	transferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex, near transition state
Biological source	Trypanosoma cruzi
Cellular location	Cytoplasm : Q27796
Total number of polymer chains	2
Total formula weight	52371.02
Authors	Focia, P.J.,Craig III, S.P.,Eakin, A.E. (deposition date: 1998-11-04, release date: 2000-03-08, Last modification date: 2023-08-23)
Primary citation	Focia, P.J.,Craig III, S.P.,Eakin, A.E. Approaching the transition state in the crystal structure of a phosphoribosyltransferase. Biochemistry, 37:17120-17127, 1998 Cited by PubMed: 9860824 DOI: 10.1021/bi9821465 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation