1T8U

Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP and tetrasaccharide substrate

1T8U の概要

• エントリーDOI: 10.2210/pdb1t8u/pdb
• 関連するPDBエントリー: 1BFB 1HY3 1S6T 1T8T
• 分子名称: heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: alpha-beta motif, substrate-binding cleft, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64409.16

構造登録者

Moon, A.F.,Edavettal, S.C.,Krahn, J.M.,Munoz, E.M.,Negishi, M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C. (登録日: 2004-05-13, 公開日: 2004-08-31, 最終更新日: 2024-04-03)

• 主引用文献: Moon, A.F.,Edavettal, S.C.,Krahn, J.M.,Munoz, E.M.,Negishi, M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C.; Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1; J.Biol.Chem., 279:45185-45193, 2004; PubMed: 15304505; DOI: 10.1074/jbc.M405013200

実験手法

X-RAY DIFFRACTION (1.95 Å)