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1T4U

Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin

Summary for 1T4U
Entry DOI10.2210/pdb1t4u/pdb
DescriptorProthrombin, Hirudin IIIA, 2-METHANESULFONYL-BENZENESULFONIC ACID 3-METHYL-5-((1-AMIDINOAMINOOXYMETHYL-CYCLOPROPYL)METHYLOXY)-PHENYLESTER, ... (5 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28507
Total number of polymer chains3
Total formula weight34830.77
Authors
Spurlino, J. (deposition date: 2004-04-30, release date: 2005-03-22, Last modification date: 2023-11-15)
Primary citationLu, T.,Markotan, T.,Coppo, F.,Tomczuk, B.,Crysler, C.,Eisennagel, S.,Spurlino, J.,Gremminger, L.,Soll, R.M.,Giardino, E.C.,Bone, R.
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
BIOORG.MED.CHEM.LETT., 14:3727-3731, 2004
Cited by
PubMed: 15203151
DOI: 10.1016/j.bmcl.2004.05.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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