1T49

Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Summary for 1T49

Entry DOI	10.2210/pdb1t49/pdb
Related	1PTY 1T48 1T4J 2HNP
Descriptor	Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, ... (4 entities in total)
Functional Keywords	allosteric inhibition, protein tyrosine phosphatase 1b, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35403.21
Authors	Wiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K. (deposition date: 2004-04-28, release date: 2004-07-20, Last modification date: 2024-02-14)
Primary citation	Wiesmann, C.,Barr, K.J.,Kung, J.,Zhu, J.,Erlanson, D.A.,Shen, W.,Fahr, B.J.,Zhong, M.,Taylor, L.,Randal, M.,McDowell, R.S.,Hansen, S.K. Allosteric inhibition of protein tyrosine phosphatase 1B. Nat.Struct.Mol.Biol., 11:730-737, 2004 Cited by PubMed: 15258570 DOI: 10.1038/nsmb803 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation