1T08

Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3

Summary for 1T08

Entry DOI	10.2210/pdb1t08/pdb
Descriptor	Beta-catenin, Beta-catenin-interacting protein 1, Adenomatous polyposis coli protein, ... (4 entities in total)
Functional Keywords	beta-catenin; wnt signal; apc; 20mer repeat; wnt signaling, cell adhesion-cell cycle complex, cell adhesion/cell cycle
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P35222 Cytoplasm (By similarity): Q9NSA3 Cell junction, adherens junction: P25054
Total number of polymer chains	3
Total formula weight	63456.42
Authors	Ha, N.-C.,Tonozuka, T.,Stamos, J.L.,Weis, W.I. (deposition date: 2004-04-07, release date: 2004-10-12, Last modification date: 2023-08-23)
Primary citation	Ha, N.-C.,Tonozuka, T.,Stamos, J.L.,Choi, H.J.,Weis, W.I. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation Mol.Cell, 15:511-521, 2004 Cited by PubMed: 15327768 DOI: 10.1016/j.molcel.2004.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation