1SZC

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases

Summary for 1SZC

Entry DOI	10.2210/pdb1szc/pdb
Related	1Q14 1Q17
Descriptor	NAD-dependent deacetylase HST2, Histone H4 peptide, ZINC ION, ... (7 entities in total)
Functional Keywords	sir2, sirtuin, histone deacetylase, gene regulation
Biological source	Saccharomyces cerevisiae (baker's yeast) More
Cellular location	Nucleus (Potential): P53686 Nucleus: P02309
Total number of polymer chains	2
Total formula weight	35805.54
Authors	Zhao, K.,Harshaw, R.,Chai, X.,Marmorstein, R. (deposition date: 2004-04-05, release date: 2004-06-15, Last modification date: 2023-11-15)
Primary citation	Zhao, K.,Harshaw, R.,Chai, X.,Marmorstein, R. Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc.Natl.Acad.Sci.Usa, 101:8563-8568, 2004 Cited by PubMed: 15150415 DOI: 10.1073/pnas.0401057101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation