1SQT

Substituted 2-Naphthamidine Inhibitors of Urokinase

Summary for 1SQT

Entry DOI	10.2210/pdb1sqt/pdb
Related	1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SQA 1SQO
Descriptor	Urokinase-type plasminogen activator, 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE (3 entities in total)
Functional Keywords	plasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00749
Total number of polymer chains	1
Total formula weight	27966.88
Authors	Wendt, M.D.,Geyer, A.,McClellan, W.J.,Rockway, T.W.,Weitzberg, M.,Zhang, X.,Mantei, R.,Stewart, K.,Nienaber, V.,Klinghofer, V.,Giranda, V.L. (deposition date: 2004-03-19, release date: 2004-04-27, Last modification date: 2011-07-13)
Primary citation	Wendt, M.D.,Geyer, A.,McClellan, W.J.,Rockway, T.W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Stewart, K.,Nienaber, V.,Klinghofer, V.,Giranda, V.L. Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors. Bioorg.Med.Chem.Lett., 14:3063-3068, 2004 Cited by PubMed: 15149645 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation