1SME

PLASMEPSIN II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH PEPSTATIN A

Summary for 1SME

Entry DOI	10.2210/pdb1sme/pdb
Related PRD ID	PRD_000557
Descriptor	PLASMEPSIN II, Pepstatin (3 entities in total)
Functional Keywords	aspartyl proteinase, aspartic proteinase, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (malaria parasite P. falciparum) More
Cellular location	Vacuole: P46925
Total number of polymer chains	4
Total formula weight	75279.25
Authors	Silva, A.M.,Lee, A.Y.,Gulnik, S.V.,Goldberg, D.E.,Erickson, J.W. (deposition date: 1996-06-11, release date: 1997-01-11, Last modification date: 2023-11-15)
Primary citation	Silva, A.M.,Lee, A.Y.,Gulnik, S.V.,Maier, P.,Collins, J.,Bhat, T.N.,Collins, P.J.,Cachau, R.E.,Luker, K.E.,Gluzman, I.Y.,Francis, S.E.,Oksman, A.,Goldberg, D.E.,Erickson, J.W. Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum. Proc.Natl.Acad.Sci.USA, 93:10034-10039, 1996 Cited by PubMed: 8816746 DOI: 10.1073/pnas.93.19.10034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation