1SKX

Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin

Summary for 1SKX

Entry DOI	10.2210/pdb1skx/pdb
Related	1ILG 1M13
Descriptor	Orphan nuclear receptor PXR, RIFAMPICIN (3 entities in total)
Functional Keywords	pregnane x receptor, rifampicin, nuclear receptor, ligand binding domain, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O75469
Total number of polymer chains	1
Total formula weight	36858.58
Authors	Chrencik, J.E.,Xue, Y.,Orans, J.O.,Redinbo, M.R. (deposition date: 2004-03-05, release date: 2005-03-08, Last modification date: 2023-08-23)
Primary citation	Chrencik, J.E.,Orans, J.O.,Moore, L.B.,Xue, Y.,Peng, L.,Collins, J.L.,Wisely, G.B.,Lambert, M.H.,Kliewer, S.A.,Redinbo, M.R. Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin Mol.Endocrinol., 19:1125-1134, 2005 Cited by PubMed: 15705662 DOI: 10.1210/me.2004-0346 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation