1SC4

Crystal structure of the human caspase-1 C285A mutant after removal of malonate

Summary for 1SC4

• Entry DOI: 10.2210/pdb1sc4/pdb
• Related: 1sc1 1sc3
• Descriptor: Interleukin-1 beta convertase (3 entities in total)
• Functional Keywords: caspase-1 after removal of malonate, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P29466 P29466
• Total number of polymer chains: 2
• Total formula weight: 30096.53

Authors

Romanowski, M.J.,Scheer, J.M.,O'Brien, T.,McDowell, R.S. (deposition date: 2004-02-11, release date: 2004-08-10, Last modification date: 2023-08-23)

• Primary citation: Romanowski, M.J.,Scheer, J.M.,O'Brien, T.,McDowell, R.S.; Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.; Structure, 12:1361-1371, 2004; PubMed: 15296730; DOI: 10.1016/j.str.2004.05.010

Experimental method

X-RAY DIFFRACTION (2.1 Å)