1SB1

Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics

Summary for 1SB1

Entry DOI	10.2210/pdb1sb1/pdb
Descriptor	Prothrombin, hirugen, SODIUM ION, ... (6 entities in total)
Functional Keywords	thrombin, inhibition, hirugen, serine protease inhibitor, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28504
Total number of polymer chains	3
Total formula weight	34949.89
Authors	Marinko, P.,Krbavcic, A.,Mlinsek, G.,Solmajer, T.,Trampus-Bakija, A.,Stegnar, M.,Stojan, J.,Kikelj, D. (deposition date: 2004-02-09, release date: 2004-06-08, Last modification date: 2011-11-16)
Primary citation	Marinko, P.,Krbavcic, A.,Mlinsek, G.,Solmajer, T.,Trampus-Bakija, A.,Stegnar, M.,Stojan, J.,Kikelj, D. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics Eur.J.Med.Chem., 39:257-265, 2004 Cited by PubMed: 15051174 DOI: 10.1016/j.ejmech.2003.12.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation