1S3K

Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide

Summary for 1S3K

Entry DOI	10.2210/pdb1s3k/pdb
Related PRD ID	PRD_900124
Descriptor	HU3S193 Fab fragment, light chain, HU3S193 Fab fragment, heavy chain, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywords	immunoglobulin fold, beta barrel, humanized antibody, antigen binding fragment, immune system
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	48631.07
Authors	Ramsland, P.A.,Farrugia, W.,Bradford, T.M.,Hogarth, P.M.,Scott, A.M. (deposition date: 2004-01-13, release date: 2004-07-13, Last modification date: 2023-10-25)
Primary citation	Ramsland, P.A.,Farrugia, W.,Bradford, T.M.,Hogarth, P.M.,Scott, A.M. Structural convergence of antibody binding of carbohydrate determinants in lewis y tumor antigens J.Mol.Biol., 340:809-818, 2004 Cited by PubMed: 15223322 DOI: 10.1016/j.jmb.2004.05.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation