1S2Q
Crystal structure of MAOB in complex with N-propargyl-1(R)-aminoindan (Rasagiline)
Summary for 1S2Q
| Entry DOI | 10.2210/pdb1s2q/pdb |
| Related | 1S2Y 1S3B 1S3E |
| Descriptor | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, ... (4 entities in total) |
| Functional Keywords | human monoamine oxidase, inhibitor binding, rasagiline, enantioselectivity, flavin, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338 |
| Total number of polymer chains | 2 |
| Total formula weight | 119593.07 |
| Authors | Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. (deposition date: 2004-01-09, release date: 2004-03-30, Last modification date: 2012-02-22) |
| Primary citation | Binda, C.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47:1767-1774, 2004 Cited by PubMed: 15027868DOI: 10.1021/jm031087c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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