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1RX9

DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)

Summary for 1RX9
Entry DOI10.2210/pdb1rx9/pdb
DescriptorDIHYDROFOLATE REDUCTASE, CALCIUM ION, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywordsoxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight18881.94
Authors
Sawaya, M.R.,Kraut, J. (deposition date: 1996-10-25, release date: 1997-04-01, Last modification date: 2023-08-09)
Primary citationSawaya, M.R.,Kraut, J.
Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36:586-603, 1997
Cited by
PubMed: 9012674
DOI: 10.1021/bi962337c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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