1RT3

AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91

1RT3 の概要

• エントリーDOI: 10.2210/pdb1rt3/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE (3 entities in total)
• 機能のキーワード: nucleotidyltransferase, hiv-1 reverse transcriptase, aids, nucleoside inhibitor, drug resistance mutation
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116391.37

構造登録者

Ren, J.,Stammers, D.K.,Stuart, D.I. (登録日: 1998-06-29, 公開日: 1999-02-16, 最終更新日: 2023-08-09)

• 主引用文献: Ren, J.,Esnouf, R.M.,Hopkins, A.L.,Jones, E.Y.,Kirby, I.,Keeling, J.,Ross, C.K.,Larder, B.A.,Stuart, D.I.,Stammers, D.K.; 3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.; Proc.Natl.Acad.Sci.USA, 95:9518-9523, 1998; PubMed: 9689112; DOI: 10.1073/pnas.95.16.9518

実験手法

X-RAY DIFFRACTION (3 Å)