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1RHU

CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A 5,6,7 TRICYCLIC PEPTIDOMIMETIC INHIBITOR

Summary for 1RHU
Entry DOI10.2210/pdb1rhu/pdb
Related1PAU 1RHJ 1RHK 1RHM 1RHQ 1RHR
DescriptorCaspase-3, (3S)-3-[({(2S)-5-[(N-ACETYL-L-ALPHA-ASPARTYL)AMINO]-4-OXO-1,2,4,5,6,7-HEXAHYDROAZEPINO[3,2,1-HI]INDOL-2-YL}CARBONYL)AMINO]-5-(BENZYLSULFANYL)-4-OXOPENTANOIC ACID, ... (4 entities in total)
Functional Keywordscysteine protease, caspase-3, apopain, cpp32, yama, complex (protease-inhibitor), hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm: P42574 P42574
Total number of polymer chains2
Total formula weight29189.19
Authors
Becker, J.W.,Rotonda, J.,Soisson, S.M. (deposition date: 2003-11-14, release date: 2004-05-11, Last modification date: 2023-09-20)
Primary citationBecker, J.W.,Rotonda, J.,Soisson, S.M.,Aspiotis, R.,Bayly, C.,Francoeur, S.,Gallant, M.,Garcia-Calvo, M.,Giroux, A.,Grimm, E.,Han, Y.,McKay, D.,Nicholson, D.W.,Peterson, E.,Renaud, J.,Roy, S.,Thornberry, N.,Zamboni, R.
Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis.
J.Med.Chem., 47:2466-2474, 2004
Cited by
PubMed: 15115390
DOI: 10.1021/jm0305523
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.51 Å)
Structure validation

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