1RHQ

CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-3 WITH A BROMOMETHOXYPHENYL INHIBITOR

Summary for 1RHQ

• Entry DOI: 10.2210/pdb1rhq/pdb
• Related: 1PAU 1RHJ 1RHK 1RHM 1RHR 1RHU
• Related PRD ID: PRD_000391
• Descriptor: Caspase-3, 5-S-benzyl-3-({N-[(5-bromo-2-methoxyphenyl)acetyl]-L-valyl}amino)-2,3-dideoxy-5-thio-D-erythro-pentonic acid (3 entities in total)
• Functional Keywords: cysteine protease, caspase-3, apopain, cpp32, yama, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 4
• Total formula weight: 58264.05

Authors

Becker, J.W.,Rotonda, J.,Soisson, S.M. (deposition date: 2003-11-14, release date: 2004-05-11, Last modification date: 2024-03-13)

• Primary citation: Becker, J.W.,Rotonda, J.,Soisson, S.M.,Aspiotis, R.,Bayly, C.,Francoeur, S.,Gallant, M.,Garcia-Calvo, M.,Giroux, A.,Grimm, E.,Han, Y.,McKay, D.,Nicholson, D.W.,Peterson, E.,Renaud, J.,Roy, S.,Thornberry, N.,Zamboni, R.; Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis.; J.Med.Chem., 47:2466-2474, 2004; PubMed: 15115390; DOI: 10.1021/jm0305523

Experimental method

X-RAY DIFFRACTION (3 Å)