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1RH0

Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine and trinucleotide GTT

Summary for 1RH0
Entry DOI10.2210/pdb1rh0/pdb
Related1JY1 1NOP 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU
Descriptor5'-D(*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... (6 entities in total)
Functional Keywordsprotein-dna complex, vanadate complex, transition state mimic, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q9NUW8
Total number of polymer chains4
Total formula weight111986.23
Authors
Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. (deposition date: 2003-11-13, release date: 2004-03-02, Last modification date: 2023-08-23)
Primary citationDavies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G.
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47:829-837, 2004
Cited by
PubMed: 14761185
DOI: 10.1021/jm030487x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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