1RC4

DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)

1RC4 の概要

• エントリーDOI: 10.2210/pdb1rc4/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, 5,10-DIDEAZATETRAHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19207.18

構造登録者

Sawaya, M.R.,Kraut, J. (登録日: 1996-11-25, 公開日: 1997-03-12, 最終更新日: 2023-08-09)

• 主引用文献: Sawaya, M.R.,Kraut, J.; Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.; Biochemistry, 36:586-603, 1997; PubMed: 9012674; DOI: 10.1021/bi962337c

実験手法

X-RAY DIFFRACTION (1.9 Å)