1RAO

CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI HPPK WITH AMP AND 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE AT 1.56 ANGSTROM RESOLUTION

Summary for 1RAO

Entry DOI	10.2210/pdb1rao/pdb
Related	1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ADENOSINE MONOPHOSPHATE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	pyrophosphokinase, pyrophosphoryl transfer, catalytic mechanism, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, 6-hydroxymethylpterin, ternary complex, substrate specificity, product release, antimicrobial agent, drug design, transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	18666.88
Authors	Blaszczyk, J.,Ji, X. (deposition date: 2003-10-31, release date: 2004-11-09, Last modification date: 2023-08-30)
Primary citation	Blaszczyk, J.,Shi, G.,Li, Y.,Yan, H.,Ji, X. Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Structure, 12:467-475, 2004 Cited by PubMed: 15016362 DOI: 10.1016/j.str.2004.02.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation