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1RA6

Poliovirus Polymerase Full Length Apo Structure

Summary for 1RA6

Related1RDR 1RA7 1RAJ 1TQL 
DescriptorGenome polyprotein, fragment RNA-directed RNA polymerase (E.C.2.7.7.48)
Functional KeywordsNUCLEOTIDYLTRANSFERASE, POLIOVIRUS, 3D, RNA-DEPENDENT, POLYMERASE, N-TERMINUS, transferase,transferase
Biological sourceHuman poliovirus 1
Cellular locationProtein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential) 
Total number of polymer chains1
Total molecular weight53468.87
Authors
Thompson, A.A.,Peersen, O.B. (deposition date: 2003-10-31, release date: 2004-08-17, modification date: 2011-07-13)
Primary citation
Thompson, A.A.,Peersen, O.B.
Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase.
Embo J., 23:3462-3471, 2004
PubMed: 15306852
DOI: 10.1038/sj.emboj.7600357
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243160.2%2.0%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

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entries available on 2014-10-22
00:00 UTC / 09:00 JST