1RA3
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
Summary for 1RA3
Entry DOI | 10.2210/pdb1ra3/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, METHOTREXATE, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19296.30 |
Authors | Sawaya, M.R.,Kraut, J. (deposition date: 1996-10-28, release date: 1996-12-23, Last modification date: 2023-08-09) |
Primary citation | Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674DOI: 10.1021/bi962337c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report