1RA0
Bacterial cytosine deaminase D314G mutant bound to 5-fluoro-4-(S)-hydroxy-3,4-dihydropyrimidine.
Summary for 1RA0
| Entry DOI | 10.2210/pdb1ra0/pdb |
| Related | 1K7O 1R9X 1R9Y 1R9Z 1RA5 1RAK 1RB7 |
| Descriptor | Cytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, ... (4 entities in total) |
| Functional Keywords | cytosine deaminase, alpha-beta barrel, hexamer, conformational change, d314g mutant, hydrolase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 47989.90 |
| Authors | Mahan, S.D.,Ireton, G.C.,Stoddard, B.L.,Black, M.E. (deposition date: 2003-10-31, release date: 2004-10-05, Last modification date: 2023-08-23) |
| Primary citation | Mahan, S.D.,Ireton, G.C.,Knoeber, C.,Stoddard, B.L.,Black, M.E. Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17:625-633, 2004 Cited by PubMed: 15381761DOI: 10.1093/protein/gzh074 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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