1R5W

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation

Summary for 1R5W

• Entry DOI: 10.2210/pdb1r5w/pdb
• Descriptor: H-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, artificial peptide (3 entities in total)
• Functional Keywords: tcr, mhc class ii, structural rearangement, signaling protein
• Biological source: Mus musculus (house mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein (Potential): P04224
• Total number of polymer chains: 6
• Total formula weight: 88320.59

Authors

Krogsgaard, M.,Prado, N.,Adams, E.,He, X.,Chow, D.C.,Wilson, D.B.,Garcia, K.C.,Davis, M.M. (deposition date: 2003-10-13, release date: 2004-03-02, Last modification date: 2021-10-27)

• Primary citation: Krogsgaard, M.,Prado, N.,Adams, E.J.,He, X.L.,Chow, D.C.,Wilson, D.B.,Garcia, K.C.,Davis, M.M.; Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation; Mol.Cell, 12:1367-1378, 2003; PubMed: 14690592; DOI: 10.1016/S1097-2765(03)00474-X

Experimental method

X-RAY DIFFRACTION (2.9 Å)