1R4Z

Bacillus subtilis lipase A with covalently bound Rc-IPG-phosphonate-inhibitor

Summary for 1R4Z

• Entry DOI: 10.2210/pdb1r4z/pdb
• Related: 1I6W 1R50
• Descriptor: Lipase, [(4R)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE (3 entities in total)
• Functional Keywords: lipase, alpha/beta hydrolase, phosphonate inhibitor, hydrolase
• Biological source: Bacillus subtilis
• Cellular location: Secreted: P37957
• Total number of polymer chains: 2
• Total formula weight: 39322.24

Authors

Droege, M.J.,Van Pouderoyen, G.,Vrenken, T.E.,Rueggeberg, C.J.,Reetz, M.T.,Dijkstra, B.W.,Quax, W.J. (deposition date: 2003-10-09, release date: 2004-10-19, Last modification date: 2024-04-03)

• Primary citation: Droege, M.J.,Boersma, Y.L.,van Pouderoyen, G.,Vrenken, T.E.,Rueggeberg, C.J.,Reetz, M.T.,Dijkstra, B.W.,Quax, W.J.; Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection; Chembiochem, 7:149-157, 2005; PubMed: 16342303; DOI: 10.1002/cbic.200500308

Experimental method

X-RAY DIFFRACTION (1.8 Å)