1R47

Structure of human alpha-galactosidase

Summary for 1R47

Entry DOI	10.2210/pdb1r47/pdb
Related	1R46
Descriptor	Alpha-galactosidase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	95749.63
Authors	Garman, S.C.,Garboczi, D.N. (deposition date: 2003-10-03, release date: 2004-03-16, Last modification date: 2024-04-03)
Primary citation	Garman, S.C.,Garboczi, D.N. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase J.Mol.Biol., 337:319-335, 2004 Cited by PubMed: 15003450 DOI: 10.1016/j.jmb.2004.01.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation