1QYX

Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstenedione and NADP

Summary for 1QYX

• Entry DOI: 10.2210/pdb1qyx/pdb
• Related: 1IOL 1JTV 1QYV 1QYW
• Descriptor: Estradiol 17 beta-dehydrogenase 1, 4-ANDROSTENE-3-17-DIONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: 17bhsd1, androstenedione, c19-steroid, nadp binding, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14061
• Total number of polymer chains: 1
• Total formula weight: 36009.74

Authors

Shi, R.,Lin, S.X. (deposition date: 2003-09-12, release date: 2004-08-03, Last modification date: 2023-08-23)

• Primary citation: Shi, R.,Lin, S.X.; Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.; J.Biol.Chem., 279:16778-16785, 2004; PubMed: 14966133; DOI: 10.1074/jbc.M313156200

Experimental method

X-RAY DIFFRACTION (1.89 Å)