6D28

Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA

Replaces:  1QY5

Summary for 6D28

• Entry DOI: 10.2210/pdb6d28/pdb
• Descriptor: Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... (4 entities in total)
• Functional Keywords: hsp90, grp94, neca, inhibitor, chaperone
• Biological source: Canis lupus familiaris (Dog)
• Total number of polymer chains: 1
• Total formula weight: 31498.26

Authors

Soldano, K.L.,Jivan, A.,Nicchitta, C.V.,Gewirth, D.T. (deposition date: 2018-04-13, release date: 2018-05-16, Last modification date: 2024-03-13)

• Primary citation: Soldano, K.L.,Jivan, A.,Nicchitta, C.V.,Gewirth, D.T.; Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.; J. Biol. Chem., 278:48330-48338, 2003; PubMed: 12970348; DOI: 10.1074/jbc.M308661200

Experimental method

X-RAY DIFFRACTION (1.75 Å)